منابع مشابه
Ligand binding by TPR domains.
Tetratricopeptide repeat (TPR) domains bind specific peptide ligands and are thought to mediate protein-protein interactions in a variety of biological systems. Here we compare peptide ligand-binding by several different TPR domains. We present specific examples that demonstrate that TPR domains typically undergo little or no structural rearrangement upon ligand binding. Our data suggest that, ...
متن کاملChaperone ligand-discrimination by the TPR-domain protein Tah1
Tah1 [TPR (tetratricopeptide repeat)-containing protein associated with Hsp (heat-shock protein) 90] has been identified as a TPR-domain protein. TPR-domain proteins are involved in protein-protein interactions and a number have been characterized that interact either with Hsp70 or Hsp90, but a few can bind both chaperones. Independent studies suggest that Tah1 interacts with Hsp90, but whether...
متن کاملLigand discrimination by TPR domains: Relevance and selectivity of EEVD- recognition in Hsp70-Hop-Hsp90 complexes RUNNING TITLE: PEPTIDE RECOGNITION MOTIFS OF HOP TPR DOMAINS
* Department of Cellular Biochemistry, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18A, D-82152 Martinsried, Germany † Institute for Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, D-72076 Tübingen, Germany ‡ Department of Structural Biology, Max-Planck-Institute for Molecular Physiology, Otto-Hahn-Straße 11, D-44227 Dortmund, Germany # present address: Department ...
متن کاملHunting TPR Domains Using Kleisli.
We have two objectives. First, we want to build a system for detecting tetratricopeptide repeats in protein sequences. Second, we want to demonstrate how the general bioinformatics database integration system called Kleisli can help build such a system easily. We achieve these two objectives by showing that short and clear programs can be written in Kleisli, using its high-level query language ...
متن کاملExploring protein domain evolution by designing new TPR-like domains
Proteins are the most abundant and diverse class of biomolecules that mediate the vast majority of biochemical processes. The functional units within a protein are the ”domains” which fold autonomously from the rest of the linear amino acid sequence in the protein. Novelty in protein function often arises as a result of gain, loss or re-shuffling of existing domains. Thus, protein domains can a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m109002200